ข้อมูลจำเพาะที่สำคัญ/ คุณสมบัติพิเศษ:
pentobarbital will decrease the level or effect of netupitant/palonosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Netupitant stelnat vatten mainly metabolized samhälle CYP3A4; avoid use in patients who are chronically using a stark CYP3A4 inducer
benzhydrocodone/acetaminophen and pentobarbital both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate
pentobarbital will decrease the level or effect of lefamulin samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of lefamulin with strong or moderate CYP3A inducers unless the benefit outweighs risks. Skärm for reduced efficacy.
Drug interactions: Most reports of clinically significant drug interactions occurring with the barbiturates have involved phenobarbital.
pentobarbital will increase the level or effect of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Skärm.
pentobarbital will decrease the level or effect of trazodone ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.
pentobarbital will decrease the level or effect of guanfacine samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Skärm Closely. Stark or moderate CYP3A4 inducers significantly reduce guanfacine plasma concentrations knipa elimination half-life.
pentobarbital will decrease the level or effect of parecoxib samhälle affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Skärm.
Nonteratogenic effects. Reports of infants suffering mild long-term barbiturate exposure in utero included the acute withdrawal syndrome of seizures knipa hyperirritability blid birth to a delayed onset of up to 14 days. (See “Drug Abuse and Dependence” section.) Published studies in pregnant primates demonstrate that the administration of anesthetic knipa sedation drugs that kloss NMDA receptors and/or potentiate GABA activity during the kalender år of peak brain development increases neuronal apoptosis in the developing brain of the offspring when used for longer than 3 hours.
Datorskärm Closely (2)pentobarbital will decrease the level or effect of buprenorphine, long-acting injection ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Patients who övergång to buprenorphine long-acting injection blid transmucosal buprenorphine coadministered with CYP3A4 inducers should vädja monitored to ensure buprenorphine plasma levels are adequate.
pentobarbital will decrease the level or effect of felodipine ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.
Pediatric use: No adequate well-controlled studies have been conducted in pediatric patients; however, safety knipa effectiveness of pentobarbital in pediatric patients is supported ort numerous studies knipa case reports cited in the literature. Pediatric dosing information for Nembutal fryst vatten described in the DOSAGE AND Förvaltning section. Published juvenile animal studies demonstrate that the administrering of anesthetic and sedation drugs, such kadaver Pentobarbital Sodium Injection USP, (Nembutal) that either block NMDA receptors or potentiate the activity of GABA during the cykel of rapid brain growth or synaptogenesis, results in widespread neuronal knipa oligodendrocyte cell loss in the developing brain and alterations in synaptic morphology and neurogenesis. Based on comparisons across species, the window of vulnerability to these changes stelnat vatten believed to correlate with exposures in the third trimester of gestation through the first several months of life, but may extend out to approximately 3 years of age in humans.
pentobarbital will decrease the level or effect pentobarbital är en typ av of celecoxib samhälle affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown.